ROLE OF TRANSPORTERS IN THE DISTRIBUTION OF PLATINUM-BASED DRUGS

Platinum derivatives used as chemotherapeutic drugs such as cisplatin and oxaliplatin have a potent antitumor activity.However, severe side effects such as nephro-, oto-, and neurotoxicity are associated with their use.Effects and side effects of platinum-based drugs are in part caused by their transporter-mediated uptake in target and non target c

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Mycorrhizal Associations and Trophic Modes in Coexisting Orchids: An Ecological Continuum between Auto- and Mixotrophy

Two distinct nutritional syndromes have been described in temperate green orchids.Most orchids form mycorrhizas with rhizoctonia fungi and are considered autotrophic.Some orchids, however, associate with fungi that simultaneously form ectomycorrhizas with surrounding trees and derive their carbon from these fungi.This evolutionarily derived conditi

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